For settling particles based on their size and density. This uses the principle of differential settling. A centrifugal force is applied to the system which aids the gravity in helping the particles to settle.

For separating immiscible liquids in the form of dispersions or emulsions. For filtration of a suspension, here the centrifugal force replaces gravity or essentially acts as the pressure difference across the filter media.

Solids can be dried by a centrifuge. It is difficult to remove the water trapped between the particles and the water sticking to the surface of water by gravity drainage especially if the viscosity of the liquid is high, also the moisture may be held in place by surface tension which must be overcome. When gravity is in-effective a centrifuge is used.

For effective breaking down of emulsions and colloids. The dispersive forces such as Brownian movement in a colloid or a emulsion is particularly high when compared to gravity, therefore a centrifugal force greater than the Brownian force is applied using a centrifuge so as to break down the emulsions or colloids.

Gases are separated using a gas centrifuge. A gas centrifuge separates gases of different densities. This application is particularly useful in nuclear industries where it is of essential importance to separate isotopes of the gases, since the different in densities of the isotopes is very minute huge centrifugal fields are required to separate them. Mass transfer is also effectively carried out by a centrifuge because it is able to provide greater efficiencies and higher output than ordinary packed column contractors. It is especially useful in situations that require compactness or to reduce the hold-up of materials which is hazardous. Desorption of oxygen from sea-water by inert gases to reduce the corrosive effect.